Know More About This Test

The ANA screen detects autoantibodies that attack the body's own cells. These antibodies are commonly present in autoimmune diseases such as lupus, rheumatoid arthritis, and scleroderma. While a positive ANA does not confirm disease, it serves as an important screening tool when autoimmune conditions are suspected.

Why Is This Test Recommended?

The ANA screen is recommended to evaluate autoimmune disorders, investigate unexplained joint pain, and assess chronic fatigue or fever. It supports diagnosis of lupus and other autoimmune conditions. Low-titer positivity may be seen in healthy individuals; interpretation requires clinical correlation.

What Do the Results Indicate?

Positive results indicate possible autoimmune activity and may require specific antibody tests. Negative results suggest autoimmune disease is unlikely. Symptoms like joint pain, skin rashes, hair loss, and persistent fatigue warrant evaluation when ANA is positive.

How Is the Test Performed and Prepared For?

A blood sample is collected through standard venipuncture. No fasting is required.

Frequently Asked Questions (FAQs)

• Does positive ANA mean lupus?
  Not always; positive ANA can occur in various autoimmune diseases and even in healthy individuals.

• Can healthy people have positive ANA?
  Yes; low-titer positive ANA can be found in healthy people, especially elderly individuals.

• Is it a definitive test?
  No; ANA is a screening test that requires clinical correlation and additional specific antibody testing.

• Is fasting needed?
  No; fasting is not required for ANA testing.

• Can ANA become negative later?
  Yes; ANA levels can fluctuate and may become negative over time or with treatment.

• Is treatment needed for positive ANA?
  Depends on symptoms; treatment is based on clinical symptoms and specific autoimmune diagnosis, not ANA alone.