Know More About This Test

The Anti–double stranded DNA test detects antibodies directed against native DNA. These antibodies are highly specific for systemic lupus erythematosus (SLE). The test is primarily used to confirm lupus diagnosis and monitor disease activity, especially kidney involvement.

Why Is This Test Recommended?

Anti-dsDNA testing is recommended to confirm lupus diagnosis, monitor disease flare-ups, assess kidney involvement, and evaluate autoimmune activity. High levels correlate with active disease and renal complications.

What Do the Results Indicate?

Positive results suggest active lupus. Results are correlated with symptoms and ANA test for comprehensive assessment. Rising levels may indicate disease flare-ups or worsening kidney involvement.

How Is the Test Performed and Prepared For?

Blood sample is collected. No fasting is required.

Frequently Asked Questions (FAQs)

1. Is it diagnostic for lupus?
   Highly specific; Anti-dsDNA antibodies are strongly associated with SLE and help confirm diagnosis, especially when combined with clinical symptoms and other tests.

2. Can levels fluctuate?
   Yes; Anti-dsDNA levels can rise and fall with disease activity, increasing during flare-ups and decreasing during remission or with treatment.

3. Is fasting required?
   No; this test does not require fasting and can be performed at any time of day.

4. Is it lifelong?
   Depends on disease; antibody levels may persist in chronic lupus, though they can decrease with effective treatment and disease control.

5. Can treatment reduce levels?
   Yes; immunosuppressive medications and appropriate lupus treatment can lower Anti-dsDNA levels and reduce disease activity over time.

6. Is it used alone?
   No; Anti-dsDNA is interpreted alongside ANA, clinical symptoms, complement levels, and other markers for comprehensive lupus assessment and management.